Higenamine is a stimulant with a variable and relatively short half-life. In some parts of the body it causes tissues to relax. In other parts of the body, such as the heart, it causes tissue to contract. It increases heart contractions and speeds up heart rate (it is not to be used in research subjects with any type of heart condition).
Higenamine is promoted in products promoted as pre-workout supplements for improving athletic performance. The World Anti-Doping Agency (WADA) recently banned higenamine last year as a performance-enhancing substance. However, our Higenaimine is sold for research use only, not for human consumption.
There is also interest in using higenamine for weight loss, cough, asthma, heart failure, and erectile dysfunction.
Higenamine, a chemical found in several plants including aconite, Annona squamosa, and Nandina domestica (sacred bamboo), is not approved by the FDA for human consumption. The purified or extracted chemical higenamine has not been studied in people. Therefore, its safety is not clear. Aconite has been shown to cause serious heart-related side effects including arrhythmias and even death.
Higenamine is a molecule derived from a variety of fruits and plants that appears to have anti-asthmatic properties via dilating the bronchial tubes (a mechanism known as Beta(2)adrenergic agonism). This mechanism is also the same one underlying the fat burning potential of ephedrine, and as such Higenamine is currently being used as a fat burner.
Currently, there is no human evidence using Higenamine and it appears to be similarly potent to some established beta(2)adrenergic agonists in preliminary studies (in regards to anti-asthmatic effects).
Beyond that mechanism, it may also exert anti-inflammatory effects and injections may be useful in a clinical setting against sepsis.
Higenamine is on the FDA’s Dietary Supplement Ingredient Advisory List as of April, 2019. These are ingredients that do not appear to be lawful ingredients in dietary supplements. The list is subject to change (check the provided link for current status).